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:: Volume 21, Issue 1 (30 2012) ::
aud 2012, 21(1): 46-53 Back to browse issues page
Auditory brainstem responses in children treated with cisplatin
Mahsa Bakhit1, Akram Pourbakht 1, Masoumeh Rouzbahani1, Shahla Ansari2, Mohammad Kamali3
1- Department of Audiology, Faculty of Rehabilitation, Tehran University of Medical Sciences, Iran
2- Clinic of Hematology and Oncology of Children, Ali Asghar Hospital, Tehran University of Medical Sciences, Iran
3- Department of Rehabilitation Management, Faculty of Rehabilitation, Tehran University of Medical Sciences, Iran
Abstract:   (6680 Views)

Background and Aim: In view of improvement in therapeutic outcome of cancer treatment in children resulting in increased survival rates and the importance of hearing in speech and language development, this research project was intended to assess the effects of cisplatin group on hearing ability in children aged 6 months to 12 years.
Methods: In this cross-sectional study, hearing of 10 children on cisplatin group medication for cancer who met the inclusion criteria was examined by recording auditory brainstem responses (ABR) using the three stimulants of click and 4 and 8 kHz tone bursts. All children were examined twice: before drug administration and within 72 hours after receiving the last dose. Then the results were compared with each other.
Results: There was a significant difference between hearing thresholds before and after drug administration (p<0.05). Right and left ear threshold comparison revealed no significant difference.
Conclusion: Ototoxic effects of cisplatin group were confirmed in this study. Insignificant difference observed in comparing right and left ear hearing thresholds could be due to small sample size. auditory brainstem responses test especially with frequency specificity proved to be a useful method in assessing cisplatin ototoxicity.

Keywords: Cisplatin, carboplatin, ototoxicity, children, auditory brainstem responses
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Type of Study: Research |
Received: 2011/05/17 | Accepted: 2011/11/6 | Published: 2013/10/14
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Volume 21, Issue 1 (30 2012) Back to browse issues page
شنوایی شناسی - دانشگاه علوم پزشکی تهران Bimonthly Audiology - Tehran University of Medical Sciences
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