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:: Volume 21, Issue 4 (19 2012) ::
aud 2012, 21(4): 19-27 Back to browse issues page
Evaluation of cognitive disorders in multiple sclerosis patients by auditory event related potential
Parisa Rasoulifard1, Ghasem Mohammadkhani 1, Saeed Farahani1, Mohammadali Sahraiyan2, Shohreh Jalaie3
1- Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Iran
2- Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Iran
3- Department of Biostatistics, School of Rehabilitation, Tehran University of Medical Sciences, Iran
Abstract:   (6769 Views)

Bachground and Aim: The involvement of central auditory nervous system is relatively prevalent in patients suffering from multiple sclerosis (MS). To understand cortex function and to investigate cognitive impairment, event related potential is considered as a valuable tool. This study was aimed to compare the amplitude and latency of the event related potentials of P300 in MS patients and normal individuals.
Methods: This cross sectional study was conducted on 21 MS patients and 27 normal cases aged 18-50 years. Auditory P300 was recorded with oddball paradigm, using two tone burst stimuli (1000 and 2000).
Results: In MS patients, mean latencies were significantly longer (p<0.001) and mean amplitude were significantly lower (p<0.001), in both males and females. Sex did not affect P300 latencies and amplitudes significantly.
Conclusion: MS patients show some degree of event related potential abnormalities. Combination of auditory P300 and neuropsychological tests may be useful to investigate cognitive impairment in MS patients.

Keywords: Multiple sclerosis, event related potential, tone burst stimulation
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Type of Study: Research |
Received: 2012/01/6 | Accepted: 2012/08/1 | Published: 2013/10/15
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Volume 21, Issue 4 (19 2012) Back to browse issues page
شنوایی شناسی - دانشگاه علوم پزشکی تهران Bimonthly Audiology - Tehran University of Medical Sciences
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