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:: Volume 20, Issue 1 (27 2011) ::
aud 2011, 20(1): 36-46 Back to browse issues page
Protective effect of N-acetylcysteine on the hearing of rabbits exposed to noise and carbon monoxide
Negin Salehi 1, Mehdi Akbari 1, Masoud Kashani 2, Hamid Haghani 3
1- Department of Audiology, Faculty of Rehabilitation, Tehran University of Medical Sciences, Iran
2- Department of Occupational Health, Kashan University of Medical Sciences, Kashan, Iran
3- Department of Statistics, Tehran University of Medical Sciences, Iran
Abstract:   (6204 Views)

Background and Aim: One of the chemical pollutions which is frequently common in industry-other than noise is carbon monoxide. The present study aimed to assess the putative protective effect of N-acetylcysteine on the function of outer hair cells of rabbits exposed simultaneously to noise and carbon monoxide.
Methods: 24 male rabbits are entered in this interventional study. After obtaining baseline distortion product otoacoustic emissions, rabits were randomely devided into four groups. The groups Included: exposed with noise and received saline, exposed with noise and carbon monoxide and received saline, exposed with noise and received N-acetylcysteine, and exposed with noise and carbon monoxide and received N-acetylcysteine. Subsequently, they were evaluated again with distortion product otoacoustic emissions in two stages (two hours and one week after the exposure). Data were recorded and analyzed using paired and independent sample t-tests.
Results: Exposure to noise, and also simultaneous exposure to noise and carbon monoxide, and moreover using N-acetylcysteine in both groups, produced significant changes in distortion product otoacoustic emissions amplitudes (p<0.005).
Conclusion: The findings of the present research reveal that simultaneous exposure to noise and carbon monoxide may potentiate noise induced hearing loss. In addition, utilizing N-acetylcysteine can be used as a preventive agent for noise induced hearing loss and to avoid its potentiation with carbon monoxide.

Keywords: N-acetylcysteine, distortion product otoacoustic emissions, noise, carbon monoxide
Full-Text [PDF 261 kb]   (1832 Downloads)    
Type of Study: Research |
Received: 2010/05/14 | Accepted: 2010/09/2 | Published: 2013/10/12
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Volume 20, Issue 1 (27 2011) Back to browse issues page
شنوایی شناسی - دانشگاه علوم پزشکی تهران Bimonthly Audiology - Tehran University of Medical Sciences
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