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:: Volume 20, Issue 1 (27 2011) ::
aud 2011, 20(1): 107-115 Back to browse issues page
Effect of N-acetylcysteine in protecting from simultaneous noise and carbon monoxide induced hair cell loss
Akram Pourbakht
Department of Audiology, Faculty of Rehabilitation, Tehran University of Medical Sciences, Iran
Abstract:   (5745 Views)

Background and Aim: N-acetylcysteine, a glutathione precursor and reactive oxygen species scavenger, is reported to be effective in reducing noise-induced hearing loss. Many workers in industry are exposed simultaneously to noise and chemical pollutants such as carbon monoxide. We investigated effectiveness of N-acetylcysteine in protecting the cochlea from simultaneous noise and carbon monoxide damages.
Methods: Twelve rabbits were exposed simeltaneously to 100 dB sound pressure level of broad band noise and carbon monoxide 8 hours a day for 5 days. One hour before exposure, experimental group received 325 mg/kg of N-acetylcysteine while normal saline was administered for the control group. The protective effect of N-acetylcysteine was evaluated 3 weeks after exposure by histological assessment of the hair cells.
Results: Simultaneous exposure to noise and carbon monoxide resulted in a considerable damage to the outer hair cells however, the inner hair cells and the pillar cells remained intact. Use of N-acetylcysteine in the experimental group significantly reduced the extent of outer hair cell loss.
Conclusion: N-acetylcysteine attenuates simultaneous noise and carbon monoxide induced hair cell damage in rabbits.
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Keywords: N-acetylcysteine, noise-induced hearing loss, carbon monoxide, hair cell, histology
Full-Text [PDF 1219 kb]   (2336 Downloads)    
Type of Study: Research |
Received: 2010/06/19 | Accepted: 2010/09/14 | Published: 2013/10/14
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Volume 20, Issue 1 (27 2011) Back to browse issues page
شنوایی شناسی - دانشگاه علوم پزشکی تهران Bimonthly Audiology - Tehran University of Medical Sciences
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