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:: Volume 20, Issue 2 (29 2011) ::
aud 2011, 20(2): 72-78 Back to browse issues page
The first survey of distribution of inherited deafness patterns in individuals referred to genetic center of Ahvaz welfare organization, Southern Iran
Ali Mohammad Foroughmand 1, Hamid Galehdari1, Gholamreza Mohammadian2, Abdolrahman Rasekh3, Jasem Ghavabesh2
1- Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Iran
2- Welfare Organization of Ahvaz, Genetic Counseling Centre, Iran
3- Department Department of Statistics, Faculty of Mathematical Sciences and Computer, Shahid Chamran University of Ahvaz, Iran
Abstract:   (6911 Views)

Background and Aim: Deafness is a heterogeneous disorder induced by genetic and environmental factors. It is the most common hereditary sensory-neural disorder that affects 1/1000 to 1/2000 of the newborns. More than 70% of hearing loss cases are caused by genetic disorders, 85% of which result from nonsyndromic autosomal recessive sensory-neural hearing loss. Up to now, more than 100 genes contributing in hearing loss have been determined. Alteration of these genes may result in hearing loss.
This study was performed to identify the inheritance patterns of deafness and its relation with ethnicity, gender and consanguineous marriages.
Methods: In this survey, data from 356 families affected by hearing loss and referred to welfare organization of Ahvaz during the time were collected based on sex, ethnic groups and relativeness.
Results: The results state a high frequency of autosomal recessive deafness caused by consanguineous marriages within Arab and non-Arab ethnic groups (p<0.05). But no significant difference in gender.
Conclusion: In conclusion, the high frequency of autosomal recessive deafness among the population with a high frequency of consanguineous marriages is considerable. The dominant pattern of deafness observed in this population was autosomal recessive.

Keywords: Syndromic deafness, non-syndromic deafness, inheritance patterns, consanguineous marriages, Arab, non-Arab population
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Type of Study: Research |
Received: 2011/01/10 | Accepted: 2011/06/1 | Published: 2013/10/14
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Volume 20, Issue 2 (29 2011) Back to browse issues page
شنوایی شناسی - دانشگاه علوم پزشکی تهران Bimonthly Audiology - Tehran University of Medical Sciences
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