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Cognitive disorders in patients with insulin-dependent type I diabetes mellitus
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| Parisa Jalilzadeh afshari1, Ghassem Mohamadkhani1, Nematollah Rouhbakhsh1, Shohreh Jalaie2, Ensieh Nasli Esfahani3 |
1- Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Iran
2- Department of Biostatistics, School of Rehabilitation, Tehran University of Medical Sciences, Iran
3- Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Iran |
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Abstract: (11562 Views) |
Background and Aim: Diabetes mellitus is a common disorder and causes a variety of central nervous system complications such as cognitive deficits. P300 auditory event related potential application is a well established neurophysiological approach in the assessment of cognitive performance. In this study, we compared the results of this application in patients with insulin-dependent (type I) diabetics mellitus and normal individuals.
Methods: In this non-interventional study, auditory P300 was measured in oddball paradigm by using two tone burst stimuli (1000 and 2000 Hz) on 25 patients with type I diabetics mellitus with the mean age of 28.76 years and 25 age-, education- and sex-matched healthy controls with the mean age of 29.68 years. The participants were enrolled by probable and category random sampling style.
Results: The mean P300 latency of the patients with type I diabetes mellitus was significantly prolonged compared with that of normal controls at all electrode sites and in both genders (p<0.001). The mean P300 amplitude of these patients was significantly lower compared with that of normal controls at all electrode sites and in both genders (p<0.001).
Conclusion: Significant prolongation in P300 latency of the patients with type I diabetes mellitus shows that auditory information processing and information categorizing are slower in them. Significant reduction in P300 amplitude of the patients with type I diabetes mellitus demonstrates that working memory in these patients cannot recognize new events and update its context in accordance with them. |
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| Keywords: Auditory event-related potential, amplitude, latency, type I diabetes mellitus |
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Type of Study: Research |
Subject:
Electrophysiology
Received: 2012/02/19 | Accepted: 2012/08/14 | Published: 2013/10/15
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