:: Volume 22, Issue 2 (7-2013) ::
aud 2013, 22(2): 55-62 Back to browse issues page
The effect of duration of multiple sclerosis and expanded disability status scale on P300
Parisa Rasoulifard 1, Ghasem Mohammadkhani1, Saeed Farahani1, Mohammadali Sahraiyan2, Shohreh Jalaie3, Sahar Shomeil Shushtary4
1- Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Iran
2- Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Iran
3- Department of Biostatistics, School of Rehabilitation, Tehran University of Medical Sciences, Iran
4- Department of Audiology, School of Rehabilitation, Jondishapour University of Medical Sciences, Ahwaz, Iran
Abstract:   (8398 Views)

Background and Aim: Multiple sclerosis (MS) is characterized with inflammation, demyelization and gliosis. It may be relapsing, remitting, or progressive. Cognitive impairment is relatively prevalent in patients wit h multiple sclerosis and as duration of disease is longer as cognition impairment is more. To understand the cognitive impairment, event related potential can be considered as a valuable tool. This study aimed to investigate the influence of duration of disease and expanded disability status scale (EDSS) on the amplitude and latency of the event related potentials of P300 in patients with multiple sclerosis.

Methods: In this cross-sectional and non-intervention study, 21 patients with multiple sclerosis with mean age of 27.8 with SD 7.1 years (between 18 to 50 years) were enrolled. The patients were selected randomly. The correlation of P300 event-related potential and oddball paradigm was assessed, using two 1000 and 2000 Hz tone burst stimulus.

Results: There was a significant correlation between the latency of P300 wave and duration of disease and expanded disability status scale (p < 0.05) there was high correlation in both electrode sites (r>0.50). The correlation of amplitude of P300 and duration of disease and expanded disability status scale was not significant (p>0.05).

Conclusion: Significant correlation between the latency of P300 and the duration of multiple sclerosis and expanded disability status scale can be a sign of central nervous system changes. Besides, there is a relation between physical disability and cognitive impairments.

Keywords: Multiple sclerosis, event related potential, tone burst stimulation, expanded disability status scale
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Type of Study: Research |
Received: 2012/01/10 | Accepted: 2012/09/5 | Published: 2013/10/15


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Volume 22, Issue 2 (7-2013) Back to browse issues page